Human ecto-5-prime nucleotidase maps to chromosome 6q14-q21. Negative feedback control of neuronal activity by microglia. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A. K., Breitinger, H.-G., Ogilvie, A.Įxpression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.īiochim. Microglial sensing of ATP, the ensuing microglia-dependent production of adenosine, and adenosine-mediated suppression of neuronal responses via the adenosine A1 receptor were essential for regulation of neuronal activity and animal behavior.Īdrian, K., Bernhard, M. AMP was then converted into adenosine by Cd73, which is expressed on microglia and other brain cells. ATP triggered recruitment of microglial protrusions and was converted by the microglial ATP/ADP hydrolyzing ectoenzyme Cd39 into AMP. Suppression of neuronal activation by microglia occurred in a highly region-specific fashion and depended on the ability of microglia to sense and catabolize extracellular ATP released upon neuronal activation by neurons and astrocytes. Microglia responded to neuronal activation by suppressing neuronal activity, and ablation of microglia amplified and synchronized neuronal activity, leading to seizures. (2020) identified microglia as critical modulators of neuronal activity and associated behavioral responses in mice. (2017) identified Elf2 (619798) as a transcription factor that negatively regulated expression of Nt5e in activated mouse liver myofibroblasts during hepatic fibrosis.īadimon et al. Low expression was detected in normal blood leukocytes.įausther et al. Monocytic differentiation resulted in a marked upregulation of CD73 mRNA. CD73 expression was hardly detectable in undifferentiated cells and following granulocyte differentiation. Granulocytic differentiation was induced by dimethylsulfoxide, and a monocytic/macrophage phenotype was induced by phorbol esters. (2000) analyzed the expression of several purinergic receptors, as well as CD73 and CD39 (ENTPD1 601752), during differentiation in a promyelocytic leukemia cell line.
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